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Furthermore, the indole core is substituted at R3 that has a carbonyl team that is also bonded into a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as being a ketone. JWH-018 is an analog of THJ-018, wherein the core indazole structure is substituted having an indole base. Pharmacology
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